A Phase 3 Randomized Study of Cystectomy plus Perioperative Pembrolizumab versus Cystectomy Alone in Cisplatin-ineligible Participants with Muscleinvasive Bladder Cancer (KEYNOTE-905)

Brief description of study

This is a research study involving the drug pembrolizumab. The purpose of this study is to: o See if pembrolizumab before and after surgery is more effective than surgery alone in patients with muscle-invasive bladder cancer (MIBC). This will be measured by tissue samples that are taken during surgery as well as imaging performed at different time points. o Test the safety of the study drug, pembrolizumab, given before and after surgery. o See how well your body handles pembrolizumab, before and after surgery. o See if pembrolizumab and surgery, compared to surgery alone, helps patients have a better quality of life. o See if pembrolizumab helps patients live longer.


Clinical Study Identifier: s18-01490
ClinicalTrials.gov Identifier: NCT03924895
Principal Investigator: Arjun Vasant Balar.


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