Perlmutter Cancer Center

This is a research study involving the drug pembrolizumab. The purpose of this study is to: o See if pembrolizumab before and after surgery is more effective than surgery alone in patients with muscle-invasive bladder cancer (MIBC). This will be measured by tissue samples that are taken during surgery as well as imaging performed at different time points. o Test the safety of the study drug, pembrolizumab, given before and after surgery. o See how well your body handles pembrolizumab, before and after surgery. o See if pembrolizumab and surgery, compared to surgery alone, helps patients have a better quality of life. o See if pembrolizumab helps patients live longer.