Perlmutter Cancer Center

The purpose of this study is to assess the safety and effectiveness of giving anastrozole, palbociclib, trastuzumab and pertuzumab to women with hormone receptor (HR)-positive, HER2-positive metastatic breast cancer. This combination of medications represents an all biologic approach and avoids chemotherapy as first line treatment of this disease. You may qualify to take part in this research study because you have metastatic (spread to other parts of your body) breast cancer that is dependent on HER2neu (a protein), estrogen (a hormone) and/ or progesterone (a hormone). Palbociclib, anastrozole, pertuzumab and trastuzumab are approved for treatment of metastatic breast cancer. Funds for conducting this research are provided by Pfizer, which is the manufacturer of palbociclib.