A Phase 3 Randomized Non-Inferiority Study of Carboplatin and Vincristine versus Selumetinib (NSC# 748727 IND# 77782) in Newly Diagnosed or Previously Untreated Low-Grade Glioma (LGG) not associated with BRAFV600E Mutations or Systemic Neurofibromatosis Type 1(NF1)

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A Phase 3 Randomized Non-Inferiority Study of Carboplatin and Vincristine versus Selumetinib (NSC# 748727 IND# 77782) in Newly Diagnosed or Previously Untreated Low-Grade Glioma (LGG) not associated with BRAFV600E Mutations or Systemic Neurofibromatosis Type 1(NF1)

Brief description of study

The purpose of the study is to find out the safety and efficacy of the drug selumetinib in treating patients with low-grade glioma. We want to know if the drug can stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. The goal of this study is to see if selumetinib works just as well as the standard treatment using carboplatin and vincristine for subjects with low-grade glioma.

Clinical Study Identifier: s20-00935

ClinicalTrials.gov Identifier: NCT04166409

Principal Investigator: Chana Glasser.

Other Investigators: Mark E Weinblatt, Christeen Azmy, Lia Phillips, Joshua Isao Chan, Sylwia Jasinski.

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Perlmutter Cancer Center

Clinical Trials & Research Studies