MULTICENTER PHASE II NEOADJUVANT AND ADJUVANT STUDY OF ALECTINIB ENTRECTINIB OR VEMURAFENIB PLUS COBIMETINIB IN PATIENTS WITH STAGES I-III NON-SMALL CELL LUNG CANCER WITH ALK ROS1 NTRK OR BRAF V600E MOLECULAR ALTERATIONS

Brief description of study

The purpose of the trial is to determine the efficacy and safety of drugs in patients with untreated non-small cell lung cancer (NSCLC) tumors. In this study, patients will receive alectinib or entrectinib or cobimetinib plus vemurafenib before surgical resection depending on the presence of the corresponding molecular alteration. We want to know if taking the study drug before surgery may shrink the tumor, making it easier for the surgeon to distinguish between normal and cancerous tissue. After this, this will help the doctor decide which treatment plan is best post-surgery.


Clinical Study Identifier: s19-00730
ClinicalTrials.gov Identifier: NCT04302025


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