Perlmutter Cancer Center

The purpose of the study is to determine the overall response rates as well as safety and tolerability of olaparib in subjects with recurrent/progressive IDH1/2-mutant solid tumors, who will be recruited to 3 cohorts: a. Glioma b. Cholangiocarcinoma c. Other solid malignant tumors. We also want to know the Progression Free Survival (PFS) or length of time during and after the treatment of a disease that a patient lives with the disease but it does not get worse. The study drug olaparib is investigational, which means that it has not been approved by the U.S Food and Drug Administration (FDA), the health authority that gives approval for new medicines to be prescribed in the United States, but the FDA has given its permission to test this agent in the current trial.