Perlmutter Cancer Center

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

• Conditions:
  Neurofibromatosis 2 (nf2)
• Age: Between 12 years - 100 years
• Gender: Male or Female

• Other Inclusion Criteria:
  

  1) Must have a pathogenic variantin the NF2 gene (either in the germline or in two NF2-related tumors) OR a confirmed diagnosis of NF2. 2) Life expectancy of greater than 1 year. 3) Must have a target NF2-related tumor with the following qualities: not amenable to surgery due to patient refusal or due to high risk for surgical complications (e.g., damage to nerve function).
  

You may not be eligible for this study if the following are true:

• 1) Participants who have had chemotherapy within a minimum of 4 weeks prior to Master Study registration (or a minimum of 5 half-lives and resolution to baseline of toxicities unless there are irreversible toxicities from prior drug that do not influence risk of next drug). 2) Participants who have received radiation to the target tumor within the last 3 years prior to Master study registration. 3) Participants who are receiving any other investigational agents.