Perlmutter Cancer Center

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

• Conditions:
  Meningioma
• Age: Between 18 years - 100 years
• Gender: Male or Female

• Other Inclusion Criteria:
  

  1) Patients must have histologically confirmed WHO grade II-III meningioma which has relapsed after prior radiation therapy with radiologically progressive or recurrent disease. 2) Patients must have measurable disease, defined as at least 1 lesion that can be accurately measured in at least one dimension as =1 cm on brain MRI but with the maximum dimension = 5 cm OR gross tumor volume < 20 cm3. 3) Patients must have at least one prior surgery with available archival formalin-fixed paraffin-embedded (FFPE) tumor blocks of the initial or recurrent meningioma.
  

You may not be eligible for this study if the following are true:

• 1) Patients who have had chemotherapy within 4 weeks (6 weeks for nitrosoureas or mitomycin C) prior to entering the study. 2) Patients who have had radiation therapy (to the site of reirradiation) within 6 months prior to entering the study. 3) Patients who have not recovered from adverse events due to prior anti-cancer therapy (i.e., have residual toxicities > Grade 1); however, alopecia, sensory neuropathy = grade 2, or other = grade 2 not constituting a safety risk based on the investigator’s judgmentare acceptable.