Perlmutter Cancer Center

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

• Conditions:
  Met-altered Advanced Non-small Cell Lung Cancer
• Age: Between 18 years - 100 years
• Gender: Male or Female

• Other Inclusion Criteria:
  

  1) Histologically confirmed Non-Small Cell Lung Cancer that is at advanced stage. Advanced is defined as unresectable or metastatic disease. Patients must have exhausted all approved available therapies. 2) Has available archival tumor tissue. 3) Willing to provide tumor tissue from newly obtained biopsy from tumor site which has not been irradiated previously and is not the only measurable lesion.
  

You may not be eligible for this study if the following are true:

• 1) Has received treatment with an approved systemic therapy within 3 weeks or has not yet recovered. 2) Has received radiation therapy or major surgery within 14 days of first administration of study drug or has not recovered (i.e. =Grade 1 or baseline) from AEs, except for laboratory changes as described in the protocol and patients with =Grade 2 neuropathy. 3) Known allergy to doxycycline or other tetracycline antibiotics.