Perlmutter Cancer Center

This trial is the first international cooperative liver tumors trial in which a consensus approach was established by investigators representing Children’s Oncology Group (COG), Société Internationale d’Oncologie Pédiatrique – Epithelial Liver Tumor Study Group (SIOPEL) and the Japanese Children’s Cancer Group (JCCG). The study builds on treatment strategies established by the most recent trials from each of the individual consortia – COG (AHEP0731), SIOPEL (SIOPEL 3 and 4) and Japanese Pediatric Liver Tumor study group (JPLT2), but provides new approaches to all stages of HB and HCC patients keeping the aforementioned goals in focus. A critical aspect of this trial is the opportunity to correlate histologic and biologic heterogeneity with response and outcomes in all risk categories, providing promise for future refinement to the newly proposed risk stratification schema.