A PHASE II SINGLE-ARM STUDY OF TOTAL BODY IRRADIATION WITH LINAC BASED VOLUMETRIC MODULATED ARC THERAPY (VMAT) AND IMAGE GUIDED RADIATION THERAPY (IGRT)

Brief description of study

The purpose of the study is to determine the safety and efficacy of delivering total body irradiation (TBI) with linac based VMAT technique for patients with hematologic malignancies requiring full-dose TBI as part of their conditioning regimen prior to allogeneic stem cell transplant. VMAT-based TBI can reduce the lung dose and improve the process of treatment in helping patients recover from therapy.

Clinical Study Identifier: s19-00664

ClinicalTrials.gov Identifier: NCT04509765

Principal Investigator: Naamit K. Gerber.

Other Investigators: Paulina Galavis, Judith D Goldberg, Jaime Andres Suarez Londono, Martha J Malin, Christine J Hitchen, Ahmad S. Al-Homsi, Sharon L Gardner, Kendra S Osterman, Elizabeth Ann Roman, Mohammad Maher Abdul Hay, Benjamin Cooper, Elizabeth A Raetz, Jingmei Hsu, David L Barbee, Jose R Teruel Antolin, Fauzia Shaikh.

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Perlmutter Cancer Center

Clinical Trials & Research Studies