A Phase Ib/II Multicenter Open-label Modular Dose-Finding and Dose Expansion Study to Explore the Safety Tolerability and Anti-tumor Activity of Trastuzumab Deruxtecan (DS-8201a T-DXd) in Combination with other Anti-cancer Agents in Patients with Metastatic HER2-positive Breast Cancer (DESTINY-Breast07)

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    Her2-positive Metastatic Breast Cancer
  • Age: Between 18 - 100 Years
  • Gender: Male or Female
  • Other Inclusion Criteria:
    1) Have been diagnosed with advanced/metastatic HER2-postiive breast cancer. 2) Have received at least 1 prior treatment line in metastatic setting. A treatment line may consist of endocrine therapy, chemotherapy and/or anti-HER2 therapy, or a combination of any of these.

You may not be eligible for this study if the following are true:

  • 1) Uncontrolled intercurrent illness, including but not limited to, ongoing or active infection, uncontrolled or significant cardiovascular disease, serious chronic gastrointestinal conditions associated with diarrhea, or psychiatric illness/social situations that would limit compliance with study requirements. 2) Has untreated central nervous system metastases identified either on the baseline brain imaging obtained during the screening period or identified.


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