Randomized single-blind placebo-controlled study on the effect of postoperative administration of single dose ketamine after mastectomy on pain
Brief description of study
The purpose of the study is to determine the effectiveness of a subanesthetic dose (0.6mg/kg) of ketamine versus placebo (saline) on postoperative pain on adult women undergoing mastectomy. Ketamine is a white, crystalline powder or clear liquid. The study drug will be administered over 30 minutes at one time point and will be administered after subject has been deemed to be stable (hemodynamically stable, awake) by the study team in recovery room. Saline is a prescription medicine used for fluid and electrolyte replenishment for intravenous administration. This is placebo drug in this study. Participants in this study will complete self-reported questionnaires. We hypothesize that single bolus dose ketamine may potentially be more helpful in certain surgical populations with high baseline depression or anxiety.
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