Birinapant and Intensity Modulated Re-Irradiation Therapy (IMRRT) for Locoregionally Recurrent Head and Neck Squamous Cell Carcinoma (HNSCC)

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    Locoregionally Recurrent Head And Neck Squamous Cell Carcinoma
  • Age: Between 18 - 100 Years
  • Gender: Male or Female
  • Other Inclusion Criteria:
    1. 1. Patients must have histologically or cytologically confirmed locally recurrent HNSCC for whom re-irradiation for local control is considered standard of care.
    2. 2. Patients must have received curative-intent platinum- and/or cetuximab-based chemoradiotherapy or radiotherapy alone.
    3. 3. Patients must have completed their last treatment dose with chemotherapy or immunotherapy at least 4 weeks (6 weeks for nitrosoureas or mitomycin C) before enrolling on study.
    4. 4. Patients must have completed their last treatment dose with radiotherapy at least 6 months before enrolling on study.

You may not be eligible for this study if the following are true:

    1. 1. Eligibility for curative-intent surgery.
    2. 2. More than 2 lines of palliative systemic therapy (platinum-, taxane- or cetuximab-based chemotherapy or immunotherapy).
    3. 3. Patients who are receiving any other investigational agents.
    4. 4. Patients with known brain metastases should be excluded from this clinical trial because of their poor prognosis and because they often develop progressive neurologic dysfunction that would confound the evaluation of neurologic and other adverse events.



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