A Phase 1 bioequivalence study between the current commercial formulation & the proposed soft gel capsule formulation of talazoparib & food effect study for the proposed talazoparib soft gel capsule formulation in participants w/ advanced solid tumors

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    Advanced Solid Tumors
  • Age: Between 18 years - 70 years
  • Gender: Male or Female
  • Other Inclusion Criteria:
    1) Histological diagnosis of recurrent, locally advanced or metastatic solid tumor that is not amenable for treatment with curative intent. 2) Participants with ovarian cancer must not have progressed during or within 1 month after the last dose of the most recent platinum-based chemotherapy. 3) Capable of giving signed informed consent. 4) Able to swallow capsules whole without breaking apart or crushing and participants who are willing and able to comply with all scheduled visits.

You may not be eligible for this study if the following are true:

  • 1) For ovarian participants: Non-epithelial tumors or ovarian tumors with low malignant potential (ie, borderline tumors) or mucinous tumors. 2) Transfusions or hematopoietic growth factors within 2 weeks of enrollment. 3) Any major surgery within 4 weeks of enrollment. 4) Any condition in which active bleeding or pathological conditions may carry a high risk of bleeding (eg, known bleeding disorder, coagulopathy or tumor involvement with major vessels).


If you are registered as a volunteer, please log in to contact the study team/express interest in this study.