A Randomized Open-Label Phase 2/3 Study Comparing Cobolimab + Dostarlimab+Docetaxel to Dostarlimab+Docetaxel to Docetaxel Alone in Participants with Advanced Nonsmall Cell Lung Cancer Who Have Progressed on Prior Anti-PD-(L)1 Therapy and Chemotherapy (Costar Lung)
Are you eligible to participate in this study?
You may be eligible for this study if you meet the following criteria:
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Conditions: Non-small Cell Lung Cancer (nsclc)
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Age: Between 18 years - 100 years
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Gender: Male or Female
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Other Inclusion Criteria:
1) Participant has histologically or cytologically proven advanced or metastatic NSCLC, including squamous or nonsquamous cell carcinoma. 2) Participant has received no more than 2 prior lines of therapy, which must include a platinum-based chemotherapy (eg, cisplatin, carboplatin) and an anti-PD-(L)1 antibody. 3) Participant has measurable disease, that is, presenting with at least 1 measurable lesion per RECIST v1.1 as determined by the local site Investigator/radiology assessment.
You may not be eligible for this study if the following are true:
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1) Participant has been previously treated with an anti-PD-(L)1 or anti-PD-L2 agent that resulted in permanent discontinuation due to an AE. 2) Participant has been previously treated with an anti-TIM-3 or anti-CTLA-4 agent or docetaxel. 3) Participant has a documented sensitizing EGFR, ALK, or ROS-1 mutation.
If you are registered as a volunteer, please log in to contact the study team/express interest in this study.