An Umbrella Study of INCMGA00012 Alone and in Combination With Other Therapies in Participants With Advanced or Metastatic Endometrial Cancer Who Have Progressed on or After Platinum-Based Chemotherapy (POD1UM-204)

Brief description of study

The purpose of the study is to determine the safety and efficacy of INCMGA00012 monotherapy or in combination with other immunotherapy or targeted agents (combinations of INCMGA00012 with epacadostat and pemigatinib) for participants who have advanced or metastatic endometrial cancer that has progressed on or after platinum-based chemotherapy. INCMGA00012 is a humanized, hinge-stabilized, IgG4? monoclonal antibody that recognizes human PD-1. The study drug INCMGA00012 is investigational, which means that it has not been approved by the U.S Food and Drug Administration (FDA), the health authority that gives approval for new medicines to be prescribed in the United States, but the FDA has given its permission to test this agent in the current trial.

Clinical Study Identifier: s20-01346 Identifier: NCT04463771

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