APOLLO: A Randomized Phase II Double-Blind Study of Olaparib Versus Placebo Following Curative Intent Therapy in Patients with Resected Pancreatic Cancer and a Pathogenic BRCA1 BRCA2 or PALB2 Mutation

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APOLLO: A Randomized Phase II Double-Blind Study of Olaparib Versus Placebo Following Curative Intent Therapy in Patients with Resected Pancreatic Cancer and a Pathogenic BRCA1 BRCA2 or PALB2 Mutation

Brief description of study

This phase II trial investigates how well the addition of olaparib following completion of surgery and chemotherapy works in treating patients with pancreatic cancer that has been surgically removed (resected) and has a pathogenic mutation in BRCA1, BRCA2, or PALB2. Olaparib is an inhibitor of PARP, an enzyme that helps repair deoxyribonucleic acid (DNA) when it becomes damaged. Blocking PARP may help keep tumor cells from repairing their damaged DNA, causing them to die. PARP inhibitors are a type of targeted therapy.

Clinical Study Identifier: s21-00636

ClinicalTrials.gov Identifier: NCT04858334

Principal Investigator: Paul E. Oberstein.

Other Investigators: Gary B Deutsch, Daniel J Becker, Marta Wioleta Wronska, Kristen Spencer, Monica Rivera, Keriann M Scavone, Nina Beri, Anastasiya Apanasyuk, Jennifer Chuy, Michael Shusterman, Rafael Winograd, Shun Yu, Alexander A Hindenburg.

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Perlmutter Cancer Center

Clinical Trials & Research Studies