GMCI plus Standard of Care Immune Checkpoint Inhibitor for Stage III/IV NSCLC Patients

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GMCI plus Standard of Care Immune Checkpoint Inhibitor for Stage III/IV NSCLC Patients

Brief description of study

The purpose of the trial is to assess the safety and efficacy of the Gene Mediated Cytotoxic Immunotherapy (GMCI) added to standard of care immune checkpoint inhibitor (ICI) for non-small Cell Lung Cancer (NSCLC) patients. We want to know if GMCI can increase the number of patients who will respond to the continued ICI. Patents may receive whatever standard of care therapy as indicated by their disease such as maintenance chemotherapy, bevacizumab , or focal radiation.

Clinical Study Identifier: s19-01928

ClinicalTrials.gov Identifier: NCT04495153

Principal Investigator: Daniel H. Sterman.

Other Investigators: Elaine Shum, Andrew Joseph DeMaio, David Mendoza, James Newman, William H. Moore, Danny Perlaza, Cristian C Papazoglu Statescu, Jamie L. Bessich, Lea Azour, Christy Lynn Spalink, Joshua K Sabari, Marissa Rybstein, Lauren G. Khanna, Natalia Cherkassky, Avital Benson, Abraham Chachoua, Elka R Travis, Jennifer Wu, Jessica Wang, Sally Lau, Salman Rafi Punekar, Jeffrey G Schneider, Vivek Murthy, Mary Lynn R Nierodzik, Samantha VanMaanen, Edna Shifteh, Samaan Rafeq, Melissa L Martinez, Vamsidhar Velcheti.

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Perlmutter Cancer Center

Clinical Trials & Research Studies