GMCI plus Standard of Care Immune Checkpoint Inhibitor for Stage III/IV NSCLC Patients

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GMCI plus Standard of Care Immune Checkpoint Inhibitor for Stage III/IV NSCLC Patients

Brief description of study

The purpose of the trial is to assess the safety and efficacy of the Gene Mediated Cytotoxic Immunotherapy (GMCI) added to standard of care immune checkpoint inhibitor (ICI) for non-small Cell Lung Cancer (NSCLC) patients. We want to know if GMCI can increase the number of patients who will respond to the continued ICI. Patents may receive whatever standard of care therapy as indicated by their disease such as maintenance chemotherapy, bevacizumab , or focal radiation.

Clinical Study Identifier: s19-01928

ClinicalTrials.gov Identifier: NCT04495153

Principal Investigator: Daniel H. Sterman.

Other Investigators: Ian John Henderson, Jennifer Wu, Vamsidhar Velcheti, Daniel Da Costa, David Mendoza, Mary Lynn R Nierodzik, Elaine Shum, Marissa Rybstein, Melissa L Martinez, Salman Rafi Punekar, Sally Lau, Vivek Murthy, Abraham Chachoua, Joshua K Sabari, Jamie L. Bessich, Samaan Rafeq, William H. Moore, Lauren G. Khanna, Edna Shifteh, Lea Azour, Natalia Cherkassky, Avital Benson, Elsa Bahiru, Jeffrey G Schneider, Cristian C Papazoglu Statescu, Jessica Wang.

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Perlmutter Cancer Center

Clinical Trials & Research Studies