GMCI plus Standard of Care Immune Checkpoint Inhibitor for Stage III/IV NSCLC Patients

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GMCI plus Standard of Care Immune Checkpoint Inhibitor for Stage III/IV NSCLC Patients

Brief description of study

The purpose of the trial is to assess the safety and efficacy of the Gene Mediated Cytotoxic Immunotherapy (GMCI) added to standard of care immune checkpoint inhibitor (ICI) for non-small Cell Lung Cancer (NSCLC) patients. We want to know if GMCI can increase the number of patients who will respond to the continued ICI. Patents may receive whatever standard of care therapy as indicated by their disease such as maintenance chemotherapy, bevacizumab , or focal radiation.

Clinical Study Identifier: s19-01928

ClinicalTrials.gov Identifier: NCT04495153

Principal Investigator: Daniel H. Sterman.

Other Investigators: Elaine Shum, Jennifer Wu, Ian John Henderson, David Mendoza, Vivek Murthy, Jessica Wang, Cristian C Papazoglu Statescu, Jeffrey G Schneider, Elsa Bahiru, Natalia Cherkassky, Lea Azour, Edna Shifteh, Lauren G. Khanna, William H. Moore, Avital Benson, Jamie L. Bessich, Joshua K Sabari, Abraham Chachoua, Sally Lau, Salman Rafi Punekar, Melissa L Martinez, Marissa Rybstein, Daniel Da Costa, Mary Lynn R Nierodzik, Samaan Rafeq, Vamsidhar Velcheti.

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Perlmutter Cancer Center

Clinical Trials & Research Studies