A Phase 2 Trial of the Combination of Polatuzumab Vedotin Venetoclax and Rituximab and Hyaluronidase Human for Relapsed and Refractory Mantle Cell Lymphoma

Brief description of study

The purpose of the study is to evaluate the activity of a novel triplet combination of rituximab and hyaluronidase human, polatuzumab vedotin, and venetoclax for relapsed Mantle Cell Lymphoma (MCL) patients. We want to know how patients respond to treatment with the regimen of rituximab and hyaluronidase human + polatuzumab vedotin + venetoclax (RSC+Pola+Ven) in relapsed/ refractory MCL. During the study, we also want to find out the best response in patients who continue on to maintenance therapy and evaluate the improvement in the depth of response.

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