NRG-BR007: A PHASE III CLINICAL TRIAL EVALUATING DE-ESCALATION OF BREAST RADIATION FOR CONSERVATIVE TREATMENT OF STAGE I HORMONE SENSITIVE HER2-NEGATIVE ONCOTYPE RECURRENCE SCORE = 18 BREAST CANCER
Brief description of study
The purpose of the study is to determine and examine whether breast conservation surgery and endocrine therapy results in a non-inferior rate of ipsilateral-breast tumor recurrence (IBTR) compared to breast conservation with breast radiation and endocrine therapy. We want to test the hypothesis that breast conservation surgery and endocrine therapy result in a non-inferior rate of invasive or non-invasive ipsilateral-breast tumor recurrence (IBTR) as compared to breast conservation, breast radiation, and endocrine therapy.
Clinical Study Identifier: s21-00798
ClinicalTrials.gov Identifier: NCT04852887
Principal Investigator:
Naamit K. Gerber.
Other Investigators:
Yelena Novik,
Maryann J Kwa,
Nina D'Abreo,
Yuliya Sundatova,
Oren Cahlon,
Sylvia Adams,
Gregory Edward Totero,
Deborah M Axelrod,
Amanda Marie Talmadge,
Jonathan Haas,
Freya R. Schnabel,
Amy N. Solan,
Benjamin Cooper,
Danielle Seidman,
Nancy Chan,
Caitlin Elizabeth Ryan,
Olivier Maisonet,
Alexander A Hindenburg,
Natalie Jill Klar,
Douglas K Marks.
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