NRG-BR007: A PHASE III CLINICAL TRIAL EVALUATING DE-ESCALATION OF BREAST RADIATION FOR CONSERVATIVE TREATMENT OF STAGE I HORMONE SENSITIVE HER2-NEGATIVE ONCOTYPE RECURRENCE SCORE = 18 BREAST CANCER

Brief description of study

The purpose of the study is to determine and examine whether breast conservation surgery and endocrine therapy results in a non-inferior rate of ipsilateral-breast tumor recurrence (IBTR) compared to breast conservation with breast radiation and endocrine therapy. We want to test the hypothesis that breast conservation surgery and endocrine therapy result in a non-inferior rate of invasive or non-invasive ipsilateral-breast tumor recurrence (IBTR) as compared to breast conservation, breast radiation, and endocrine therapy.


Clinical Study Identifier: s21-00798
ClinicalTrials.gov Identifier: NCT04852887
Principal Investigator: Naamit K. Gerber.
Other Investigators: Yelena Novik, Maryann J Kwa, Nina D'Abreo, Amy N. Solan, Oren Cahlon, Yuliya Sundatova, Benjamin Cooper, Thomas B. Daniels, Deborah M Axelrod, Jonathan So, Amanda Marie Talmadge, Freya R. Schnabel, Caitlin Elizabeth Ryan, Sylvia Adams, Jonathan Haas, Alexander A Hindenburg, Gregory Edward Totero, Olivier Maisonet, Douglas K Marks, Natalie Jill Klar, Danielle Seidman.


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