Site for NRG-BR007: A PHASE III CLINICAL TRIAL EVALUATING DE-ESCALATION OF BREAST RADIATION FOR CONSERVATIVE TREATMENT OF STAGE I HORMONE SENSITIVE HER2-NEGATIVE ONCOTYPE RECURRENCE SCORE = 18 BREAST CANCER

Brief description of study

Site for Primary Objective To evaluate whether breast conservation surgery and endocrine therapy results in a non-inferior rate of ipsilateral-breast tumor recurrence (IBTR) compared to breast conservation with breast radiation and endocrine therapy. Primary Hypothesis Breast conservation surgery and endocrine therapy results in a non-inferior rate of invasive or non-invasive ipsilateral-breast tumor recurrence (IBTR) as compared to breast conservation, breast radiation, and endocrine therapy.


Clinical Study Identifier: s21-00798
ClinicalTrials.gov Identifier: NCT04852887
Principal Investigator: Naamit K. Gerber.
Other Investigators: Amanda Marie Talmadge, Yan Fon Mei, Danielle Seidman, Natalie Jill Klar, Freya R. Schnabel, Yuliya Sundatova, Jonathan So, Sylvia Adams, Yael Simons, Caitlin Elizabeth Ryan, Benjamin Cooper, Maryann J Kwa, Nina D'Abreo, Yelena Novik, Deborah M Axelrod, Gregory Edward Totero, Olivier Maisonet, Oren Cahlon, Amy N. Solan, Thomas B. Daniels, Jonathan Haas, Nancy Chan, Alexander A Hindenburg, Douglas K Marks.


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