ACNS2021: A Phase 2 Trial of Chemotherapy followed by Response-Based Whole Ventricular & Spinal Canal Irradiation (WVSCI) for Patients with Localized Non-Germinomatous Central Nervous System Germ Cell Tumor

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    Localized Non-germinomatous Central Nervous System Germ Cell Tumor
  • Age: Between 3 Year(s) - 30 Year(s)
  • Gender: Male or Female
  • Other Inclusion Criteria:
    1. Patients must be newly diagnosed with localized primary CNS NGGCT of the suprasellar and/or pineal region by pathology and/or serum or CSF elevation of AFP above institutional normal or > 10 ng/mL or hCGß > 100 mIU/mL.
    2. Patients with any o

You may not be eligible for this study if the following are true:

    1. Patients with tumors located outside the ventricles (i.e., basal ganglia, thalamus); mature teratoma and non-elevated markers upon tumor sampling at diagnosis.
    2. Patients who have received any prior tumor-directed therapy for their diagnosi


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