A Phase 1b First-in-human Dose Escalation and Expansion Multicenter Study of XMT-1660 in Participants with Solid Tumors

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    Previously Treated Participants With Metastatic Tnbc, Hr+/her2- Or Her2+ Breast Cancer, Endometrial Cancer, Or Ovarian, Fallopian Tube, Or Primary Peritoneal Cancer
  • Age: Between 18 Year(s) - 100 Year(s)
  • Gender: Female
  • Other Inclusion Criteria:
    1. Participant has proven recurrent or advanced solid tumor and has disease progression after treatment with available anti-cancer therapies known to confer benefit or is intolerant to treatment.
    2. Participant must have cardiac left ventricular ejection fraction =50%
    3. Participant must have adequate organ function within 14 days prior to cycle 1, day 1 of treatment
    4. ER+ breast cancer: must have had prior hormonal therapy
    5. TNBC: must have had prior chemotherapy

You may not be eligible for this study if the following are true:

    1. Participant has had major surgery within 28 days of starting study treatment, systemic anticancer therapy within the time period of 28 days.
    2. Has a diagnosis of additional malignancy that required active treatment.
    3. Participants with human immunodeficiency virus (HIV) infection are excluded from study entry. An HIV test is required during Screening.



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