A Phase 1/1b Open-label Multicenter Study to Investigate the Safety Tolerability Pharmacokinetics and Antitumor Activity of KIN-2787 in Participants with BRAF and/or NRAS Mutation-positive Solid Tumors

Brief description of study

This is a 2-part, open-label, multicenter, dose escalation and dose expansion study in participants with rapidly accelerated fibrosarcoma, homolog B (BRAF) mutation-positive and/or neuroblastoma RAS (NRAS) mutation-positive tumors designed to evaluate the safety, tolerability, and pharmacokinetics (PK) of KIN-2787, a pan-rapidly accelerated fibrosarcoma (RAF) small molecule kinase inhibitor; to determine a recommended Phase 2 dose (RP2D) of KIN-2787 for further clinical development; and to assess the objective response to KIN-2787 therapy alone and in combination with binimetinib, a mitogen-activated protein kinase (MEK) inhibitor.


Clinical Study Identifier: s22-00213
ClinicalTrials.gov Identifier: NCT04913285
Principal Investigator: Janice Mehnert.
Other Investigators: Nila Theresa De La Rosa, Maya Dimitrova, Jeffrey S. Weber, Carol M Lee, Kristen Spencer, Jonathan B Kahn, Kathleen M Madden, Rafael Winograd.


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