Perlmutter Cancer Center

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

• Conditions:
  Advanced Or Metastatic Solid Tumors
• Age: Between 18 Year(s) - 100 Year(s)
• Gender: Male or Female

• Other Inclusion Criteria:
  

  1. Paticipants must have histologically confirmed metastatic or locally advanced solid tumor not amenable to curative treatment with surgery and/or radiation. 2. Evidence of homozygous loss of CDKN2A (null) and/or MTAP (null) or lost MTAP expression in the tumor tissue. 3. MTAP-null and/or CDKN2A-null or lost MTAP expression solid tumor for which no standard therapy exists; or standard therapy has failed or not available/tolerated; or in the investigator’s opinion, standard therapy does not result in meaningful clinical benefit.
  

You may not be eligible for this study if the following are true:

• 1. Presence of primary brain cancer. 2. Presence of hematological malignancy or lymphoma. 3.Spinal cord compression or active brain metastases or leptomeningeal disease from non-brain tumors. 4. History of other malignancy within the past 2 years, with the following exceptions: - Malignancy treated with curative intent and with no known active disease present for = 2 years before enrollment and felt to be at low risk for recurrence by the treating physician. - Adequately treated non-melanoma skin cancer or lentigo maligna without evidence of disease. - Adequately treated cervical carcinoma in situ without evidence of disease. - Adequately treated breast ductal carcinoma in situ without evidence of disease