A Phase 1/1b Open-label Multicenter Study to Investigate the Safety Tolerability Pharmacokinetics Pharmacodynamics and Anti-tumor Activity of KIN-3248 in Participants with Advanced Tumors Harboring FGFR2 and/or FGFR3 Gene Alterations
Brief description of study
This study is designed for patients who have Advanced Tumors Harboring FGFR2 and/or FGFR3 Gene Alterations. This study is evaluating the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and anti-tumor activity of KIN-3248, a next-generation, irreversible, small molecule pan-fibroblast growth factor receptor (FGFR) inhibitor. This study will determine a recommended Phase 2 dose (RP2D) of KIN-3248 for further clinical development and assess the objective response to KIN-3248 therapy in participants with advanced tumors harboring pertinent FGFR2 and/or FGFR3 gene alterations.. This is also a first in human (FIH), two-part, open-label, multicenter, dose escalation and dose expansion study.
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