A Phase 1 Open-Label Multi-Center Safety and Efficacy Study of PRT3789 in Participants with Select Advanced or Metastatic Solid Tumors with a SMARCA4 Mutation

Brief description of study

This is a study to test a new drug called PRT3789 for safety and effectiveness in treating certain types of advanced or metastatic solid tumors. The study will enroll participants with a specific gene mutation to find the highest non-toxic dose of PRT3789. PRT3789 is designed to inhibit the activity of a protein called SMARCA2. When SMARCA4 is mutated, cancer cells utilize SMARCA2, and thus, by inhibiting the activity of SMARCA2, PRT3789 may help to slow or stop the growth of cancer cells.

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