A PHASE I/IB SINGLE ARM STUDY OF TWO FRACTION SBRT WITH DOMINANT LESION SIB FOR THE TREATMENT OF LOCALIZED PROSTATE CANCER

Brief description of study

Phase I/IB, single arm trial of Two-Fraction SBRT with an MRI directed, dominant intraprostatic lesion, simultaneous integrated boost based on genomic classification in the treatment of localized prostate cancer. Primary endpoint will be physician-reported grade 2 or higher CTCAE toxicity. Secondary endpoints are: EPIC quality of life, PSA Nadir, and Phoenix Definition Biochemical failures as well as Disease Free Survival, Overall Survival, and MFS.


Clinical Study Identifier: s22-01306
ClinicalTrials.gov Identifier: NCT05864196
Principal Investigator: Jonathan W Lischalk.
Other Investigators: David Jaihun Byun, Mary K O'Keeffe, Victor Ricardo Adorno Febles, Todd J Carpenter, Anthony Corcoran, Moses M Tam, Samir Taneja, Angela Tong, Jonathan Haas, Aaron Edward Katz, William C Huang, Maya Dimitrova, Michael J. Zelefsky, Hank Ng, David R. Wise.


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