A Modular Open-label Phase I/II Study to Evaluate the Safety Tolerability Pharmacokinetics and Efficacy of EP0031 in Patients with Advanced RET-altered Malignancies

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    Ret Fusion-positive Nsclc, : Ret Mutation-positive Mtc
  • Age: Between 18 Year(s) - 100 Year(s)
  • Gender: Male or Female
  • Other Inclusion Criteria:
    1. Documented RET-altered malignancy as determined by a DNA- or RNA-based assay of tumour tissue and/or a liquid biopsy
    2. Tissue or liquid biopsy at screening for retrospective confirmation of RET aberration status, after progression on first-generation SRI
    3. Ability to swallow and retain oral medication

You may not be eligible for this study if the following are true:

    1. Any other known major driver gene alterations except RET
    2. Any other invasive malignancy which has been active or treated within the past 3 years
    3. Spinal cord compression or unstable brain metastases



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