A Multi-phase Dose-Escalation followed by an Open-label Randomized Crossover Study of Oral ASTX030 (Cedazuridine and Azacitidine Given in Combination) Versus Subcutaneous Azacitidine in Subjects with Myelodysplastic Syndromes (MDS) Chronic Myelomon

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    Myelodysplastic Syndromes (mds), Chronic Myelomonocytic Leukemia (cmml), Or Acute Myeloid Leukemia (aml)
  • Age: Between 18 Year(s) - 100 Year(s)
  • Gender: Male or Female
  • Other Inclusion Criteria:
    1. Confirmed MDS, CMML, and other MDS/MPN or AML who will benefit from taking oral ASTX030
    2. Proper kidney and liver organ function
    3. No major surgery within 2 weeks before first study treatment

You may not be eligible for this study if the following are true:

    1. A stomach or small intestine sore that is not under control
    2. Other sicknesses that are not controlled or have infections caused by bacteria, viruses, or fungi that are not controlled; it might be too risky for your health, interfere with the ingestion of oral ASTX030 or compromise the integrity of the study outcomes
    3. Had cancer before you entered this study; (it's acceptable as long as it was treated well and it was either breast cancer that stayed in one place, or a type of skin cancer that only affects a small area). Other types of cancer that spread to other parts of your body may make it too risky for you to participate in this study.



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