AN OPEN-LABEL MULTICENTER PHASE 2 STUDY EVALUATING THE EFFICACY AND SAFETY OF CRG-022 A CD22-DIRECTED AUTOLOGOUS CHIMERIC ANTIGEN RECEPTOR (CAR) T-CELL THERAPY IN PARTICIPANTS WITH RELAPSED/REFRACTORY LARGE B-CELL LYMPHOMA AFTER CD19-DIRECTED CAR T-CELL THERAPY

Brief description of study

CD19-directed autologous CAR T-cell therapy has changed the treatment landscape for patients with relapsed/refractory (R/R) large B-cell lymphoma (LBCL). Nonetheless, up to 60% of patients undergoing autologous CD19-directed CAR T-cell therapy experience disease progression due to treatment resistance, including CD19-negative relapse; outcomes for these patients are poor. Therapy directed at an alternative B-cell-specific antigen may be able to overcome resistance to CD19-directed therapy. CRG-022 is an autologous CAR T-cell product targeting CD22, a common B-cell antigen widely expressed in LBCL. This study aims to evaluate the safety and the efficacy of CRG-022 in the treatment of participants with R/R LBCL that has progressed after CD19-directed CAR T-cell therapy, an area of high unmet need.


Clinical Study Identifier: s23-00080
ClinicalTrials.gov Identifier: NCT05972720
Principal Investigator: Catherine M Diefenbach.
Other Investigators: Jaime Andres Suarez Londono, Nicole Karich, Eileen Zhao, Maureen E Musatto, Jamie M Pavlonnis, David Kaminetzky, Kathryn Dowling, Marissa Hornacek, Kenneth B Hymes, Rafael C Singson, Amanda Marie Ferris, Tibor Moskovits, Oscar B Lahoud, Jingmei Hsu, Sejal Singh, Anna C Hatzinikolaou, Maxim Kreditor, Rena Kandinova, Mohammad Maher Abdul Hay, Shella Saint Fleur-Lominy, Kelsey Stocker, Ellaine R Yap, Laura P. Diaz, Michael L. Grossbard, Kristen Randolph Jordan, Bruce G Raphael, Jamie Robin Nemrow, Chelsea F Curione.


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