A Phase 1b Study to Evaluate the Safety Tolerability and Preliminary Efficacy of ATP150/ATP152 VSV-GP154 and Ezabenlimab (BI 754091) in Patients with KRAS G12D/G12V Mutated Pancreatic Ductal Adenocarcinoma

Brief description of study

This study is designed for patients with resected KRAS G12D/G12V mutated pancreatic cancer.This is an open-label, phase 1b study comprising of two parts (safety and immunogenicity part andrandomized efficacy part) to evaluate the safety, tolerability, preliminary efficacy, and immunogenicityof a heterologous prime-boost vaccine (protein and viral vector) strategy, in which approximately 85 patients with KRAS G12D/G12V mutated pancreatic cancer will be enrolled in the following treatment parts of the study:

Part A (Safety and Immunogenicity Phase) – locally advanced or metastatic PDAC

Part B (Safety and Immunogenicity Combination Phase) – resected or locally advanced PDAC

Part C (Efficacy Phase)- resected PDAC




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