A PHASE III RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED STUDY EVALUATING ATEZOLIZUMAB AND BEVACIZUMAB WITH AND WITHOUT TIRAGOLUMAB IN PATIENTS WITH UNTREATED LOCALLY ADVANCED OR METASTATIC HEPATOCELLULAR CARCINOMA

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    Hepatocellular Carcinoma
  • Age: Between 18 Year(s) - 100 Year(s)
  • Gender: Male or Female
  • Other Inclusion Criteria:
    1. Locally advanced or metastatic and/or unresectable HCC with diagnosis confirmed by histology/cytology or clinically by AASLD criteria in cirrhotic participants
    2. Disease that is not amenable to curative surgical and/or locoregional therapies
    3. No prior systemic treatment (including systemic investigational agents) for locally advanced or metastatic and/or unresectable HCC

You may not be eligible for this study if the following are true:

    1. Pregnancy or breastfeeding, or intention of becoming pregnant during the study or within 5 months after the final dose of atezolizumab, within 6 months after the final dose of bevacizumab, and within 90 days after the final dose of tiragolumab
    2. Prior treatment with CD137 agonists or immune checkpoint blockade therapies, including, but not limited to, anti.CTLA-4, anti.PD-1, anti.PD-L1, and anti-TIGIT therapeutic antibodies
    3. Treatment with investigational therapy within 28 days prior to initiation of study treatment



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