A Phase 1/2 Study of the Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor NVL-655 in Patients with Advanced NSCLC and Other Solid Tumors (ALKOVE-1)

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    Non-small Cell Lung Cancer
  • Age: Between 18 Year(s) - 100 Year(s)
  • Gender: Male or Female
  • Other Inclusion Criteria:
    1. Phase 1: Histologically or cytologically confirmed locally advanced or metastatic solid tumor with a documented ALK rearrangement or activating ALK mutation detected by certified assay (i.e. CLIA in the US).
    2. Progressed on prior ALK inhibitors (which may include ceritinib, alectinib, brigatinib, lorlatinib).
    3. Patients with other solid tumors must have previously received at least one prior systemic anticancer therapy or be those for whom no satisfactory standard therapy exists.

You may not be eligible for this study if the following are true:

    1. Known allergy/hypersensitivity to excipients of NVL-655.
    2. Symptomatic congestive heart failure.
    3. History of pneumonitis.



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