Perlmutter Cancer Center

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

• Conditions:
  Advanced Non-small Cell Lung Cancer
• Age: Between 18 Year(s) - 100 Year(s)
• Gender: Male or Female

• Other Inclusion Criteria:
  

  1. Histologically or cytologically confirmed diagnosis of advanced (metastatic or unresectable) NFE2L2/KEAP1/CUL3 mutant non-small cell lung cancer
  2. Progression after 1 platinum-based chemotherapy regimen and PD(L)-1 antibody therapy either sequentially or concurrent with chemotherapy, where indicated, for Stage IV non-small cell lung cancer
  3. Treatment with neo-adjuvant / adjuvant platinum-based therapy that progressed within 6 months of treatment are permitted to participate

  
  

You may not be eligible for this study if the following are true:

• 1. Impaired cardiac function or clinically significant cardiac disease, or risk factors at screening
  2. Presence of symptomatic CNS metastases, or CNS metastases that require local CNS-directed therapy
  3. Patients treated with the following therapy that cannot be discontinued 7 days prior to the start of the study and for the duration of the study