Perlmutter Cancer Center

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

• Conditions:
  Other Female Genital, Ovary
• Age: Between 18 Year(s) - 99 Year(s)
• Gender: Female

• Other Inclusion Criteria:
  

  In order to participate in this study the following conditions must be met:

  1. Age >18 years or the minimum legal adult age (whichever is greater) at the time the ICF is signed.
  2. Subjects with histologically or cytologically documented high-grade serous OVC, high-grade endometrioid OVC, primary peritoneal cancer, or fallopian tube cancer.
  3. Has at least 1 measurable lesion evaluated by computed tomography (CT) or magnetic resonance imaging (MRI) according to RECIST v1.1 per investigator assessment.

  
  

You may not be eligible for this study if the following are true:

• You will not be able to participate in this study if you have:

  1. Clear cell, mucinous, or sarcomatous histology, mixed tumors containing any histology, or low-grade/borderline OVC.
  2. Clinically active brain metastases, spinal cord compression, or leptomeningeal carcinomatosis, defined as untreated or symptomatic, or requiring therapy with steroids or anticonvulsants to control associated symptoms. Subjects with untreated and asymptomatic brain metastases or subjects with treated brain metastases who are no longer symptomatic and who require no treatment with steroids may be included in the study if they have recovered from the acute toxic effect of radiotherapy, at the investigator’s discretion.
  3. Any of the following within the past 6 months prior to randomization: cerebrovascular accident, transient ischemic attack, or other arterial thromboembolic event.