Phase II: Adaptive De-escalation of Radiation Therapy Dose In Favorable Risk HPV-Positive Oropharyngeal Carcinoma (ART)

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Phase II: Adaptive De-escalation of Radiation Therapy Dose In Favorable Risk HPV-Positive Oropharyngeal Carcinoma (ART)

Brief description of study

The main goal of this study is to determine if deescalating chemoradiation treatment based on early tumor shrinkage at mid-treatment can result in similar cancer cure rates as standard treatment but fewer side effects and better quality of life.

Clinical Study Identifier: s17-00330

ClinicalTrials.gov Identifier: NCT03215719

Principal Investigator: Kenneth S Hu.

Other Investigators: Elizabeth M Coffey, Paulina Galavis, Jacqueline Mojica, Mark S Persky, Elaine Shum, Janet H. Van Cleave, Michael E. Pacold, Colin Hill, Milan R Amin, Danny Perlaza, Elise M Zahriah, Nora Russo, Monica Rivera, Joshua K Sabari, Marissa Rybstein, Caitlin Elizabeth Ryan, Ann M Riccobene, Gene H Kim, Tuyet-Phuong N Tran, Zujun Li, Adam S Jacobson, Catherine M Concert, Moses M Tam.

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Perlmutter Cancer Center

Clinical Trials & Research Studies