AALL15P1 A Groupwide Pilot Study to Test the Tolerability and Biologic Activity of the Addition of Azacitidine (IND# 133688 NSC# 102816) to Chemotherapy in Infants with Acute Lymphoblastic Leukemia (ALL) and KMT2A (MLL) Gene Rearrangement

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    Acute Lymphoblastic Leukaemia [all]
  • Age: Between 36 years - 1 years
  • Gender: Male or Female
  • Other Inclusion Criteria:
    1. Infants less than 1 year of age on the date of diagnosis are eligible; infants must be >36 weeks gestational age at the time of enrollment. 2. Patients must have newly diagnosed B lymphoblastic leukemia (also termed B-precursor acute lymphoblastic leukemia) or acute leukemia of ambiguous lineage (ALUL), which includes mixed phenotype acute leukemia (MPAL). 3. CNS status must be determined based on a sample obtained prior to the administration of any systemic or intrathecal chemotherapy

You may not be eligible for this study if the following are true:

  • 1.Patients with known absence of KMT2A-Rearrangement leukemia prior to enrollment. 2. Patients with Down syndrome. 3. Patients with secondary B-ALL that developed after treatment of a prior malignancy with cytotoxic chemotherapy.


If you are registered as a volunteer, please log in to contact the study team/express interest in this study.