A Randomized Phase 2 Study of Losartan and Nivolumab in Combination with FOLFIRINOX and SBRT in Localized Pancreatic Cancer (Stand up to Cancer)
Brief description of study
This multi-center, open-label, rando ized Phase II study will evaluate the effectiveness of the addition of the angiotension II type receptor blocker Losartan, or the combination of losartan and immunotherapy (nivolumab) to FOLFIRINOX (leucovorin, 5-FU, irinotecan, oxaliplatin) followed by SBRT (Stereotactic Body Radiation Therapy) and surgery. This will be benchmarked against a control arm of FOLFIRINOX followed by SBRT and surgery. An exploratory arm (not randomized) will be included for patients already on an ACE/ARB (angiotensin-converting enzyme inhibitor / angiotensin-receptor blocker). The study will include borderline resectable and locally advanced pancreatic cancers.
If you are registered as a volunteer, please log in to contact the study team/express interest in this study.
