A phase I open-label dose-escalation study to investigate the safety pharmacokinetics pharmacodynamics and clinical activity of GSK3368715 in participants with solid tumors and DLBCL

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    Solid Tumors And Dlbcl
  • Age: Between 18 years - 99 years
  • Gender: Male or Female
  • Other Inclusion Criteria:
    1) Histologically- or cytological-confirmed diagnosis of solid tumor malignancy that is metastatic or non-resectable. 2) Have received all standard treatment options or are no longer eligible for additional standard treatment options. 3) Relapse or refractory disease after at least 1 but not more than 4 lines of prior therapy. 4) At least 1 measurable site of disease according to the Lugano Classification. The site of disease must be greater than 1.5 cm in the long axis regardless of short axis measurement or greater than 1.0 cm in the short axis regardless of long axis measurement, and clearly measurable in 2 perpendicular dimensions.

You may not be eligible for this study if the following are true:

  • 1) History of malignancy other than the disease under study. 2) Primary central nervous system (CNS) tumors, Glioblastoma multiforme (GBM), symptomatic or untreated leptomeningeal or brain metastases or spinal cord compression. 3) Any severe or uncontrolled systemic diseases. 4) Any clinically significant gastrointestinal (GI) abnormalities that may alter absorption such as malabsorption syndrome or major resection of the stomach and/or bowels.


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