RANDOMIZED PHASE II TRIAL OF HYPOFRACTIONATED DOSE-ESCALATED PHOTON IMRT OR PROTON BEAM THERAPY VERSUS CONVENTIONAL PHOTON IRRADIATION WITH CONCOMITANT AND ADJUVANT TEMOZOLOMIDE IN PATIENTS WITH NEWLY DIAGNOSED GLIOBLASTOMA

Brief description of study

The purpose of this study is to compare a different radiation therapy schedule and higher radiation dose [higher dose group] to the standard dose of radiation therapy [standard dose group]. Both groups will receive usual chemotherapy, temozolomide. The higher radiotherapy dose could shrink your cancer, but it could also cause side effects. This study will allow the researchers to know whether this higher dose is better, the same, or worse than the usual approach. To be better, the study should increase life by six months or more compared to the usual approach. Two methods of giving radiation therapy will also be compared. They are proton beam radiation and intensity-modulated radiation. There will be about 606 people taking part in this study.




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