Perlmutter Cancer Center

The purpose of this study is to compare any good and bad effects of using proton therapy to using photon therapy. Photon therapy is the usual treatment approach for your brain cancer. Proton therapy uses a beam of proton particles to send radiation inside the body to the tumor. This study will allow the researchers to know whether proton therapy is better, the same, or worse than the usual approach. Proton therapy may have less negative effects on brain function than photons because less brain is exposed to radiation when proton therapy is used. However, proton therapy might also be associated with more frequent tumor recurrences. After receiving protons or photons, both groups will receive a usual chemotherapy, temozolomide. To be eligible for this study, your tumor must have a mutation in a gene called IDH. The study team will verify that your tumor has an IDH mutation. To be better, proton therapy should result in less decline in your thinking skills months to years after treatment.