A PHASE II RANDOMIZED TRIAL OF PROTON VS. PHOTON THERAPY (IMRT) FOR COGNITIVE PRESERVATION IN PATIENTS WITH IDH MUTANT LOW TO INTERMEDIATE GRADE GLIOMAS

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    Idh Mutant, Low To Intermediate Grade Gliomas
  • Age: Between 18 years - 100 years
  • Gender: Male or Female
  • Other Inclusion Criteria:
    1) Tumor tissue must be available for submission for central pathology review 2) Grade II and III gliomas IDH mutant gliomas including; diffuse astrocytoma, anaplastic astrocytoma, oligodendroglioma, anaplastic oligodendroglioma, oligoastrocytoma, anaplastic oligoastrocytoma 3) Only English or French speaking patients are eligible to participate as the cognitive assessments are only available in these languages 4) Pre-operative MRI imaging of the brain available for radiation planning

You may not be eligible for this study if the following are true:

  • 1) Prior invasive malignancy (except non-melanomatous skin cancer) unless disease free for a minimum of 3 years. (For example, carcinoma in situ of the breast, oral cavity or cervix are permissible) 2) Prior cranial radiotherapy or radiotherapy to the head and neck where potential field overlaps would exist 3) Prior chemotherapy or radiotherapy for any brain tumor 4) Definitive evidence of multifocal disease


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