8 clinical trials found.
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A phase III multicenter randomized open-label trial to evaluate efficacy and safety of ribociclib with endocrine therapy as an adjuvant treatment in patients with hormone receptor-positive HER2-negative early breast cancer (New Adjuvant TriAl with Ribociclib [LEE011]: NATALEE).
The purpose of the trial is to evaluate the efficacy and the safety of ribociclib when given in combination with endocrine (hormonal) therapy, compared to ...Phase
Interventional
TRIAL ROLE: Sub Investigator
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S1418/BR006 A Randomized Phase III Trial to Evaluate the Efficacy and Safety of MK-3475 as Adjuvant Therapy for Triple Receptor-Negative Breast Cancer with > 1 cm Residual Invasive Cancer or Positive Lymph Nodes (ypN+) After Neoadjuvant Chemotherapy.
If you have been diagnosed with triple negative breast cancer (TNBC) you may qualify to participate in a clinical trial investigating the investigational drug MK-3475 ...
Phase
Interventional
TRIAL ROLE: Sub Investigator
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Phase II Study of Pembrolizumab and Nab-paclitaxel in HER-2 Negative Metastatic Breast Cancer
The goal of this Phase II study is to evaluate the safety/tolerability and clinical activity of the combination of nab-paclitaxel and the antibody against ...Phase
Interventional
TRIAL ROLE: Sub Investigator
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Prone Partial Breast Irradiation (PBI): A Prospective Randomized Trial Comparing Five Versus Three Fractions
If you have been diagnosed with Stage 0 or I breast cancer, also known as ductal carcinoma in situ (DCIS) or T1 breast cancer, you ...
Phase
Interventional
TRIAL ROLE: Sub Investigator
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A Multicenter Phase I/II Trial of Anastrozole Palbociclib Trastuzumab and Pertuzumab in HR-positive Her2-positive Metastatic Breast Cancer (ASPIRE)
The purpose of this study is to assess the safety and effectiveness of giving anastrozole, palbociclib, trastuzumab and pertuzumab to women with hormone receptor (HR ...Phase
Interventional
TRIAL ROLE: Sub Investigator
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A Phase 1 Multi-Targeted Study to Promote Anti-Tumor Immunity in ER Positive HER2 Negative Advanced Breast Cancer
The purpose of the study is to look at the safety and tolerability for immunotherapy combinations to determine how these drugs work for participants with ...Phase
Interventional
TRIAL ROLE: Sub Investigator
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A Phase 1 Multicenter Open-label Dose-Exploration and Dose-Expansion Study Evaluating the Safety Tolerability Pharmacokinetics and Efficacy of AMG 650 in Subjects With Advanced Solid Tumors
The purpose of this study is to obtain initial information on the safety and tolerability (good or bad effects) of a drug given by mouth ...Phase
Interventional
TRIAL ROLE: Sub Investigator
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A randomized Phase I/II trial of fulvestrant and abemaciclib in combination with copanlisib (FAC) versus fulvestrant and abemaciclib alone (FA) for endocrine-resistant hormone receptor positive HER2 negative metastatic breast cancer (FAC vs FA)
The purpose of the study is to determine the effects (good and bad) of adding copanlisib to the usual therapy of fulvestrant and abemaciclib in ...Phase
Interventional
TRIAL ROLE: Sub Investigator
