13 clinical trials found.
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A phase II multicenter single arm study of oral BGJ398 in adult patients with advanced or metastatic cholangiocarcinoma with FGFR2 gene fusions or other FGFR genetic alterations who failed or are intolerant to platinum-based chemotherapy
The purpose of this study is find out if the drug BGJ398 is safe and has beneficial effects in people who have advanced cholangiocarcinoma (biliary ...Phase
Interventional
TRIAL ROLE: Sub Investigator
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Immunotherapy alone or in Combination with Chemotherapy in Induction/Maintenance or Postprogression in Advanced Nonsquamous Non-Small Cell Lung Cancer (NSCLC) with Immunobiomarker SIGNature-driven Analysis
This study is being done to answer the following questions: Does starting treatment with the immunotherapy drug, MK-3475 (pembrolizumab), alone, instead of a combination of ...Phase
Interventional
TRIAL ROLE: Sub Investigator
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A PHASE II RANDOMIZED CONTROLLED TRIAL OF NIVOLUMAB IN COMBINATION WITH BMS-986253 OR CABIRALIZUMAB IN ADVANCED HEPATOCELLULAR CARCINOMA (HCC) PATIENTS
The purpose of this research study is to determine whether treatment with Cabiralizumab or HuMax-IL8 in combination with Nivolumab has additional benefit to Nivolumab treatment ...Phase
Interventional
TRIAL ROLE: Sub Investigator
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A Randomized Phase 2 Study of Losartan and Nivolumab in Combination with FOLFIRINOX and SBRT in Localized Pancreatic Cancer (Stand up to Cancer)
This multi-center, open-label, rando ized Phase II study will evaluate the effectiveness of the addition of the angiotension II type receptor blocker Losartan, or the ...Phase
Interventional
TRIAL ROLE: Sub Investigator
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A Phase I Open Label Study of GSK3359609 Administered alone in Combination with Anticancer Agents in Subjects with Selected Advanced Solid Tumors
If you have been diagnosed with selected advanced or recurrent solid tumors including bladder cancer, cervical cancer, colorectal cancer, esophageal cancer with squamous cell histology ...
Phase
Interventional
TRIAL ROLE: Sub Investigator
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A Double Blind Placebo-Controlled Trial of Eflornithine and Sulindac to Prevent Recurrence of High Risk Adenomas and Second Primary Colorectal Cancers in Patients with Stage 0-III Colon or Rectal Cancer Phase III Preventing Adenomas of the Colon with Eflornithine and Sulindac (PACES)
If you have been diagnosed with colon or rectal cancer, you may qualify to participate in a study evaluating the combination of the drugs eflornithine ...
Phase
Interventional
TRIAL ROLE: Sub Investigator
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A Phase 1 Open-Label Study of the Safety Tolerability and Efficacy of KPT-9274 A Dual Inhibitor of PAK4 and NAMPT in Patients with Advanced Solid Malignancies or Non-Hodgkin's Lymphoma (PANAMA)
if you are newly diagnosed with non-Hodgkin's lymphoma or advanced solid malignancies, you may qualify to participate in a clinical trial. The main goal ...
Phase
Interventional
TRIAL ROLE: Sub Investigator
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A randomized phase II trial of fulvestrant with or without Ribociclib after progression on aromatase inhibition plus cyclin-dependent kinase 4/6 inhibition in patients with unresectable or metastatic hormone receptor positive HER2 negative breast cancer
This is a phase II, multi-center, randomized, double-blind, placebo-controlled trial to evaluate fulvestrant +/- ribociclib in patients with HR+HER2- breast cancer who have previously progressed ...
Phase
Interventional
TRIAL ROLE: Sub Investigator
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Randomized Phase II And Phase III Studies Of Individualized Treatment For Nasopharyngeal Carcinoma Based On Biomarker Epstein Barr Virus (EBV) Deoxyribonucleic Acid (DNA)
There are two study questions we are asking in this randomized phase II/III trial based on a blood biomarker, Epstein Barr virus (EBV) deoxyribonucleic ...
Phase
Interventional
TRIAL ROLE: Sub Investigator
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Randomized Double-Blind Phase III Trial of Vitamin D3 Supplementation in Patients with Previously Untreated Metastatic Colorectal Cancer (SOLARIS)
The purpose of the study is to determine the efficacy and safety of how well vitamin D3 given with standard chemotherapy and bevacizumab works in ...Phase
Interventional
TRIAL ROLE: Sub Investigator
