7 clinical trials found.
-
Phase 2 Trial of XL184 (Cabozantinib) an Oral Small-Molecule Inhibitor of Multiple Kinases in Children and Young Adults with Refractory Sarcomas Wilms Tumor and Other Rare Tumors
The purpose of the trial is to determine the safety and efficacy of the drug called XL184 (Cabozantinib) in people with sarcomas, Wilms tumor or ...
Phase
Interventional
TRIAL ROLE: Principal Investigator
-
A Phase 2 Study of Reduced Therapy for Newly Diagnosed Average-Risk WNT-Driven Medulloblastoma Patients
The primary purpose of the study is to determine if a reduced dose of radiation to the whole brain and spine and less chemotherapy can ...
Phase
Interventional
TRIAL ROLE: Principal Investigator
-
Phase 3 Accelerated BEP Trial: A randomised phase 3 trial of accelerated versus standard BEP chemotherapy for patients with intermediate and poor-risk metastatic germ cell tumours
The primary purpose of the study is to determine if accelerated BEP ((Bleomycin, Etoposide, and cisPlatin) is effective and tolerable for patients with advanced germ ...
Phase
Interventional
TRIAL ROLE: Principal Investigator
-
NCI-COG PEDIATRIC MATCH (MOLECULAR ANALYSIS FOR THERAPY CHOICE)-PHASE 2 SUBPROTOCOL OF OLAPARIB IN PATIENTS WITH TUMORS HARBORING DEFECTS IN DNA DAMAGE REPAIR GENES
The primary purpose of the study is to determine the effectiveness and tolerability of the investigational drug olaparib for patients diagnosed with advanced solid tumors, ...
Phase
Interventional
TRIAL ROLE: Principal Investigator
-
A Phase 3 Study of I-Metaiodobenzylguanidine (I-MIBG) or Crizotinib Added to Intensive Therapy for Children with Newly Diagnosed High-Risk Neuroblastoma (NBL) (IND# 134379)
?The primary purpose of the study is to determine the effectiveness and tolerability of the experimental drug I-MIBG or the experimental drug crizotinib for high ...
Phase
Interventional
TRIAL ROLE: Principal Investigator
-
Utilizing Response and Biology Based Risk Factors to Guide Therapy in Patients with Non-High Risk Neuroblastoma
The primary purpose is to determine the effectiveness and tolerability of eliminating therapy as the initial approach for infants <12 months of age and <18 ...
Phase
Interventional
TRIAL ROLE: Principal Investigator
-
A Phase 3 Study of I-Metaiodobenzylguanidine or Crizotinib Added to Intensive Therapy for Children with Newly Diagnosed High-Risk Neuroblastoma (NBL) (IND# 134379)
?The primary purpose of the study is to assess the effectiveness and safety of targeted radiopharmaceutical therapy with 131I-MIBG or crizotinib for patients with high-risk ...
Phase
Interventional
TRIAL ROLE: Principal Investigator
